Enzymes Vs. Antibiotics for Otitis Externa


Otitis externa is an itchy infection of the external ear canal.
An estimated 80% of cases are due to environmental or
food allergies. Acute otitis externa in dogs and cats can take
two to four weeks to resolve, and chronic ear infections can
take months.

Allergies in pets can’t be cured, but their complications can
be managed. In some cases, a prophylactic regimen might
be needed for the rest of the animal’s life due to frequent
reoccurrences of otitis. In rare cases, animals may be placed
on systemic antibiotics in conjunction with topical antibiotics.
Systemic antibiotics have their own set of potential adverse
effects, including but not limited to gastrointestinal upset or
allergic reaction.

Repeated and sustained use of antibiotics can cause genetic
alterations within groups of bacteria, and may lead to a
microorganism becoming resistant to an initially effective
antimicrobial drug. There are three main strategies microbes
use to develop antibiotic resistance: they prevent the drug from
reaching its target, they alter the target, and they inactivate the
antibiotics. Repeated and improper use of antibiotics is also
the suspected culprit in the development of highly resistant
microbes such as methicillin-resistant Staphylococcus aureus
and Pseudomonas aeruginosa.

ZYMOX® Otics are a line of enzymatic ear solutions
that work without antibiotics and won’t contribute to
antibiotic resistance. They include an otic solution with
1% hydrocortisone; an otic without hydrocortisone; and an
advanced formulation for highly resistant cases (i.e. MRSA,
Pseudomonas). All the products share a patented formulation of
enzymes that works synergistically to form its antibacterial,
anti-fungal and anti-yeast properties.

Unlike antibiotics, which require the ear to be cleaned before
application of a topical, the enzymes within ZYMOX products
mean that no pre-cleaning is required. This is because the
pus and infectious debris serve as a catalyst to initiate the
enzymatic process. This feature has proven to be a real benefit
in increasing pet owner compliance because the products are
so easy to use.

When considering which ZYMOX product to use and
recommend consider the following:
• With 1% hydrocortisone: For use in red infl amed ears in
the presence of infection.
• Advanced Formula: For use in highly resistant cases such
as MRSA and Pseudomonas. This otic features additional
enzymes formulated to destroy the biofi lm slime layer that
protects and hides the DNA of a microbe.
• Without hydrocortisone: For long-term use as well as for
pregnant or lactating females.

There are many mechanisms by which bacteria may become
resistant to antibiotics, and numerous factors play a role.
ZYMOX products provide safe, effective, long-term solutions
that won’t cause bacterial resistance and can be very easily
administered by the pet owner. For the best results, follow
the directions, carefully read the warnings on the label, and
complete the full course of use.