Laser therapy at the appropriate wavelength and power density has many applications for many conditions.

Laser therapy is a treatment modality that has been utilized for decades, but is finally finding its place in mainstream veterinary medicine. Interest in the application of therapeutic laser for the treatment of various conditions has grown dramatically as anecdotal reports, clinical case reports, and systematic study results have become available. Therapeutic laser has been incorporated into treatments that address diverse conditions including:

• Skin wounds
• Tendon and ligament injuries
• Trigger points
• Edema
• Lick granulomas
• Muscle injuries
• Nervous system injury and neurologic conditions
• Osteoarthritis
• Post-operative incisions and tissues
• Pain

In order to understand how to best leverage therapeutic laser for appropriate treatment applications, it is important to understand the basics of laser technology, whether using therapeutic laser as a standalone modality or as a part of a larger treatment protocol.

Laser fundamentals

The term “laser” is an acronym that stands for “light amplification by stimulated emission of radiation”, and describes a device that emits radiation in the form of a flow of photons of light energy. Therapeutic laser has been referred to as “low level” laser and “cold” laser, but these are considered obsolete terms. They were intended to distinguish therapy lasers from surgical lasers. Surgical lasers rely on different media – gas or solid – to incise or ablate tissues as an alternative to using a scalpel or cautery, respectively.

Therapeutic lasers help modulate cellular functions through a process called photobiomodulation, a photochemical process in which photons from a laser source interact with the target cells via a non-thermal mechanism to cause either

stimulation or inhibition of biochemical pathways. While the precise mechanism for photobiomodulation is not completely understood, it appears that cytochrome C, located in the mitochondria, serves as an important photoreceptor. Once light is absorbed by cytochrome C, mitochondrial respiration and ATP production increase, leading to global tissue effects.

Laser light is monochromatic (one wavelength), coherent (all photons travel in the same phase and direction), and collimated (minimal divergence of the laser beam over a distance). These three properties allow the therapy laser light to be focused on a specific area of the body, to penetrate the skin without heating or damaging it, and to interact with tissue with few side effects. The beam should be aimed at 90° to the surface of the area being treated. Wavelength influences the depth of penetration, and longer wavelengths penetrate deeper into the tissues. The optimal wavelength range for tissue photobiomodulation appears to be 650nm to 1,300nm; at longer wavelengths the laser beam penetrates deeper into tissue while minimizing absorption by the pet’s hair and skin pigment. Superficial wounds and joint injuries can be treated with shorter wavelengths, while longer wavelengths are better suited to treat muscle injuries.

The power of the therapeutic laser matters in terms of the dose delivered, and the time needed to deliver the treatment dose. Power is a unit of time, and is expressed in watts (W) or milliwatts (mW). One watt is one Joule of energy delivered per second, and the laser dose is typically expressed as Joules/cm2 – the energy delivered over a surface area. The most commonly used therapeutic lasers in veterinary medicine are Class III lasers, which may deliver energy from 1mw to 500mw, and Class IV lasers, which deliver power at greater than 500mw.

• A lower watt laser provides less energy delivery to deeper tissues so the time needed to deliver a treatment is longer. A lower power laser is better suited for treating superficial structures because of the limited power density to drive photons into the deeper tissues.
• A higher watt laser allows the treatment to be delivered over a shorter period and involves administering the laser energy with a sweeping motion over the affected area. This sweeping motion may provide more complete coverage of the treatment area and may cover surrounding areas that could be causing secondary or referred pain. Pulsing of the laser beam may provide less heating of tissues at the surface while allowing for an adequate level of energy to reach the deeper target tissues, but more research is needed to define the optimal approach to a pulsed laser beam.

Benefits of therapeutic laser

Most responses of cells and tissues to therapeutic laser have been studied in in vitro models (cell culture). There appear to be many distinct benefits to using therapeutic laser for its tissue effects. Therapeutic laser has been demonstrated to relieve both chronic and acute pain by modulating peripheral nerve function and nerve conduction velocities. Laser energy increases the speed of tissue repair by increasing local microcirculation as well as stimulating the immune system and reducing inflammation. Laser energy also enhances collagen and muscle tissue development, which in turn enhances healing.

There are several important “downstream” tissue effects from the application of laser light. These effects include:

• Neovascularization
• Angiogenesis
• Collagen synthesis which enhances wound healing
• Stimulation of nerve healing
• Enhanced healing of tendons, cartilage, and bones
• Reduced swelling from injury
• Modulation of degenerative tissue changes
• Mitigation of CNS damage following traumatic brain injury and spinal cord injury

When creating a treatment protocol for therapeutic laser, it is important to consider these effects in order to maximize patient outcome. The actual time the tissue is exposed to light energy may also affect the outcome.

Laser safety

There are some important safety considerations when incorporating therapeutic laser into treatment protocols. Protective glasses with lenses rated to the specific wavelength of the treatment laser are important for both humans and patients in order to protect retinal tissue. Laser energy should not be applied over a pregnant uterus, over tumors, over an open fontanel, over the growth plates of immature animals, or over the thyroid gland. Be careful if the pet has a tattoo, black fur, or black skin because of the potential for light absorption and tissue heating.

What does the research show?

Most of the basic research done on therapeutic laser has been conducted in cell culture, and conducted in humans; however, extrapolation to veterinary medicine is reasonable.

Because of the stimulation of fibroblast activity by laser light, this may affect collagen production to facilitate healing of wounds and burns. Studies suggest a laser dose of 1 J/cm2 to 5 J/cm2. Very high doses appear to inhibit healing. Both bone and cartilage appear to respond well to therapeutic laser. Osteochondral lesions of the stifle responded well to therapeutic laser used intraoperatively. Laser may also support cartilage during times that a joint must be immobilized.

In human studies, the application of therapeutic laser for osteoarthritis is controversial. While some study participants appeared to have a positive outcome, overall results were unclear. Likewise, tendon treatment with therapeutic laser is controversial. Overall, however, laser therapy may improve collagen fiber organization, leading to enhanced tendon and ligament healing. The nervous system responds well to therapeutic laser for pain management, although the exact mechanism of suppression of central sensitization via laser is unknown.

Applying therapeutic laser to dogs and cats

The optimal wavelengths, intensities, and dosages for laser therapy in pets have not yet been adequately studied or determined, but this is sure to change as studies are designed and as more case-based information is reported. To maximize laser penetration, the pet’s hair should be clipped. When treating traumatic, open wounds, the laser probe should not contact the tissue, and the dose often quoted is 2 J/cm2 to 8 J/cm2. When treating a post-operative incision, a dose of 1 J/cm2 to 3 J/ cm2 per day for the first week after surgery is described. Lick granulomas may benefit from therapeutic laser once the source of the granuloma is identified and treated. Delivering 1 J/cm2 to 3 J/cm2 several times per week until the wound is healed and the hair is re-growing is described. Treatment of osteoarthritis (OA) in dogs and cats using therapeutic laser is commonly described. The laser dose that may be most appropriate in OA is 8 J/cm2 to 10 J/cm2 applied as part of a multi-modal arthritis treatment plan. Finally, tendonitis may benefit from laser therapy due to the inflammation associated with the condition.

Laser therapy of the future

Therapeutic laser is of special interest in the area of nerve regeneration, particularly in human medicine. Veterinary patients experience peripheral nerve issues as they age, as osteoarthritis develops and progresses, in the wake of intervertebral disk disease, and when they develop nervous system decline as occurs in degenerative neuropathy/myelopathy. Photobiomodulation has been demonstrated to support nerve regeneration, re-innervation of denervated muscle, and functional recovery following peripheral nerve injury. This is an area of active research that promises to provide a significant impact on both human and veterinary patients.

Summary

Therapeutic laser clearly has a role in the treatment and management of multiple conditions in companion animals. There is strong evidence to suggest that light energy at the appropriate wavelength and power density has the ability to provide modulation of tissues at the cellular level to enhance healing. There are multiple important clinical benefits that should be considered, prompting the practitioner to introduce therapeutic laser into specific patient treatment protocols. Therapeutic laser has been thought to be one of the most underutilized treatment modalities in veterinary medicine. As more and more formal studies into the uses of therapeutic laser in animal models are completed, and more and more cases are presented, there is no doubt the use of therapeutic lasers will continue to expand.

Therapeutic laser’s time has come in the treatment of many different conditions in companion animals. While it is not a panacea, it can certainly make a positive difference in the outcomes our patients experience.

Laser Q&A

Laser technology has been changing over the years. IVC talked to three manufacturers about their products and the changing technology

Q: Have there been any recent changes/ improvements in your technology?

Meghan Collins, Cutting Edge Laser Technologies: “Our newest model features 75 watts of peak power and comes standard with acupuncture and intraoral tips.”

Amanda Hoffmeyer, Litecure (Companion Therapy Laser): “Newer features include built-in, condition-specific treatment protocols with software that changes dosing parameters based on the species being treated, the size of the patient, as well as the patient’s individual body type, skin color, and hair coat color and length. Other recent dosing innovations like Perfect Protocol™ calculate dosage based on user defined preferences for the most customized treatments ever. Our software also tracks patient treatment history, and our patented Deep Tissue Treatment applicator ensures each patient is getting the optimal dose every time.”

Lisa Miksis, Respond Systems: “We recently added 670nm red laser as an option, and are seeing its use increasing in veterinary dermatology, and for post-surgical healing.We are also see growth potential in the use for laser in assistance with “dentals”, and down the line as a tool for anti-bacterial/anti-microbial applications.”

Q: Briefly describe your equipment and what you see as its main benefit.

MC: “MLS (Multiwave Locked System) Therapy Lasers feature patented technology that delivers therapeutic wavelengths, 808nm (anti-edemic and anti-inflammatory) and 905nm (analgesic), allowing a tissue penetration depth of 3cm to 4cm. An energetic synergy is created when delivering these wavelengths that produces greater anti-inflammatory and analgesic effects than either can produce on its own, while minimizing the risk of thermal damage. This unique combination and synchronization of continuous and pulsed emissions characterizes MLS and distinguishes it from other Class IV lasers.”

AH: “The Companion Therapy Laser provides the perfect balance between user defined treatment protocols and condition-specific treatments creating optimal dosing for consistent clinical outcomes. The vast array of application-specific treatment applicators allows the user to pick the perfect treatment head for each target area.  Having this kind of versatility and flexibility optimizes the ability of our laser to treat many different conditions in multiple species and ensure consistent outcomes in decreasing pain and inflammation as well as speeding healing.”

LM: “Respond Systems has been manufacturing laser therapy and pulsed electromagnetic field (PEMF) therapy systems for veterinarians since 1983. We see our lasers as a “jack of all trades” in the clinic. Using low levels of laser light to stimulate healing, our lasers provide safe fast treatments for animals needing rehab, for wounds or quick treatment of lick granuloma and otitis, or for faster recovery following surgery. We offer a choice of lasers to fi t a wide variety of practice needs; from solo or mobile practitioners, on to the largest referral hospitals.”

Q: What are the most common problems vets/ rehab staff use your equipment for?

MC: “Our lasers are used for chronic and acute inflammatory conditions, wounds, and intraoperatively – even over plates and screws.”

AH: “Therapy laser is used most commonly for acute painful/ inflammatory conditions such as otitis, pyotraumatic dermatitis, wounds/abscesses, and for post-operative procedures to help decrease pain and speed incisional healing. Chronic conditions such as osteoarthritis are very commonly treated with therapy laser and benefit from this safe, non-invasive technology.  In a rehab setting, therapy laser treats acute soft tissue injuries such as muscular or tendon/ligament strains/sprains, and is used for chronic neurological conditions and rehab as well as post-orthopedic procedure rehabilitation therapy.”

LM: “On a daily basis, we receive calls inquiring about soft tissue injury in the athletic dog.  The conditions our lasers are treating in agility and working dogs include wound healing, Iliopsoas strains, muscle injury and bicipital tenosynovitis or bursitis. Respond Systems lasers also treat a wide variety of conditions in geriatric patients. Vets and PTs are treating hip and elbow dysplasia, arthritis, IVDD, and cervical spine issues. Our lasers are an excellent adjunct to traditional needle acupuncture.”

References

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