Bowl with hemp oil, leaf and seeds on white background, top view

Not all cannabis (hemp) is created equal. There are hundreds, if not thousands of different cannabis (hemp) cultivars in the world. Cannabis itself is made up of thousands of compounds, including terpenes and cannabinoids. These two compounds, along with flavonoids and tocopherols, work together synergistically in what is known as the “entourage effect”. The entourage effect changes with each genetic strain because the profile of the terpenes and cannabinoids differs in each strain. Certain strains will produce certain benefits from the profile of its compounds; if the profile changes, the results may change as well.

HOW DO YOU KNOW IF A PRODUCT IS STRAIN SPECIFIC?

  1. Make sure the company is vertically integrated, meaning they handle everything from farming to the final product.
  2. Ensure they are using a full spectrum oil. Otherwise, the oil will be void of certain compounds such as terpenes, flavonoids, tocopherols, and tetrahydrocannabinol.
  3. Look for the strain name on the product — for example, Cherry Abacus or Charlotte’s Web. These are names of actual strains used in the product.

Cultivar specificity ensures you will receive the same product time after time, and pets will have consistency in the way their bodies respond to the pharmacokinetics and pharmacodynamics of hemp. If you are using hemp that is not cultivar specific, you could be doing a trial-and-error experiment every time you order a new bottle.

TERPENE AND CANNABINOID PROFILES

Terpenes not only make up the smell and flavor of the plant but also contain many health-related beneficial properties.1 Thousands of terpenes have been documented thus far, existing in a range of plants from citrus fruits to pine trees. Terpenes contain antimicrobial, antioxidant, and anti-inflammatory properties. They play a role in offering “relevant protection under oxidative stress conditions in different diseases, including liver, renal, neurodegenerative and cardiovascular diseases, cancer, diabetes, as well as in aging processes”.2 Another aspect of hemp products that needs to be considered is the cannabinoid profile. Both the cannabinoid and terpene profile make up the genomic fingerprint of the hemp plant.3 The cannabinoid profile represents the active cannabinoids in that specific strain, as well as the concentration between cannabidiol and tetrahydrocannabinol. Hemp strains can vary from a few cannabinoids to hundreds, depending upon the purpose of the product.

THE ENTOURAGE EFFECT

The entourage effect comes into play when a myriad of ingredients are combined to exert a synergistic effect, including cannabinoids, endocannabinoids, terpenes, phytocnanabinoids, and tetrahydrocannabinol.5 When all these ingredients are combined, they have a much stronger effect on the body than isolated cannabinoids do on their own.5 HempMy Pet™ utilizes their own genetic line of Cherry Abacus™ hemp that is bred and produced at our local farm in Colorado. Our full-spectrum hemp extract combines CBD, CBG, CBC, terpenes, flavonoids, tocopherols, and under 0.03% THC to create a cultivar specific product full of bioactive, human-grade and vegan ingredients that are beneficial for animals. We are incredibly proud to be cultivar specific so we can ensure every customer receives the same product every single time they purchase from us. Each batch is third party analyzed and tested to ensure purity, potency and safety for every pet.

1 Bergman, M. E., Davis, B., & Phillips, M. A. (2019). Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action. Molecules (Basel, Switzerland), 24(21), 3961. https://doi.org/10.3390/molecules24213961.

2 González-Burgos, E., & Gómez-Serranillos, M. P. (2012). Terpene compounds in nature: a review of their potential antioxidant activity. Current medicinal chemistry, 19(31), 5319–5341. https://doi.org/10.2174/092986712803833335.

3 Project CBD. CBD-Rich Strains. Project CBD: How to Use CBD & Cannabis. https://www.projectcbd.org/medicine/cbd-rich-strains.

4 Valastro, C., Campanile, D., Marinaro, M., Franchini, D., Piscitelli, F., Verde, R., Di Marzo, V., & Di Bello, A. (2017). Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. BMC veterinary research, 13(1), 309. https://doi.org/10.1186/s12917-017-1245-7.

5 Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British journal of pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x.

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Elisha is originally from Los Angeles, California and moved to Colorado to attend Colorado State University. She graduated in 2015 with a Bachelor of Science in Animal Science and a minor in Business Administration. Throughout her undergraduate career, she fell in love with research and working with animals. She went back to school and finished her Master of Science in Toxicology in Summer the of 2017. Elisha hopes to return to school in the fall of 2021 to pursue her PhD in Public Health. She is currently working for HempMy Pet™ as Head of Research, Toxicologist. Elisha thrives in a scientific writing environment and is specifically interested in holistic preventative health. Her favorite topic to write about is how the endocannabinoid system plays a preventative maintenance role through the ingestion of full-spectrum hemp and how individuals will respond differently depending upon their idiosyncratic mechanisms within their body. In her spare time, Elisha enjoys fostering puppies to keep her on her toes and has foster failed twice! She has adopted two dogs from Animal Friends Alliance whom she met fostering; a two-year-old puggle mix named Bailey and a puggle puppy named Dudley. She loves to be outside and explore beautiful Colorado with her dogs through backpacking, camping, and hiking.

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